Evaluation of light/dark cycle in anxiety- and depressive-like behaviors after regular treatment with methylphenidate hydrochloride in rats of different ages.

@article{Gomes2011EvaluationOL,
  title={Evaluation of light/dark cycle in anxiety- and depressive-like behaviors after regular treatment with methylphenidate hydrochloride in rats of different ages.},
  author={Karin M. Gomes and Renan Pedra Souza and Cec{\'i}lia G. In{\'a}cio and Samira S Valvassori and Gislaine Zilli R{\'e}us and M{\'a}rcio Martins and Clarissa Martinelli Comim and Jo{\~a}o Quevedo},
  journal={Revista brasileira de psiquiatria},
  year={2011},
  volume={33 1},
  pages={
          55-8
        }
}
OBJECTIVE Methylphenidate hydrochloride is the most widely used medication for treatment and management of attention-deficit hyperactivity disorder. However, the chronic effects of methylphenidate hydrochloride on anxiety- and depressive-like rat behaviors remain poorly investigated. In this context, the present study evaluated the effects of treatment with methylphenidate hydrochloride on anxiety- and depressive-like behaviors using young and adult rats during the light and the dark cycle… CONTINUE READING

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