Evaluation of lens epithelial cell differentiation by quantitation of MP26 mRNA relative to gamma-crystallin mRNA in initiation of galactose cataracts in the rat.

It is well established that in response to feeding of galactose to four-week-old rats cataracts develop (Unakar, Genyea, Reddan & Reddy, Exp. Eye Res. 26, 123-33, 1978). Initiation of cataracts leads to epithelial cell proliferation. In the lens, the main intrinsic membrane protein, MP26, is recognized as a fiber cell-specific gene product, and gamma… CONTINUE READING