Evaluation of leishmanicidal activity and cytotoxicity of Ricinus communis and Azadirachta indica extracts from western Kenya: in vitro and in vivo assays

@article{Jumba2015EvaluationOL,
  title={Evaluation of leishmanicidal activity and cytotoxicity of Ricinus communis and Azadirachta indica extracts from western Kenya: in vitro and in vivo assays},
  author={Bernard N. Jumba and C. Anjili and J. Makwali and J. Ingonga and R. Nyamao and S. Marango and J. K. Choge and C. Khayeka–Wandabwa},
  journal={BMC Research Notes},
  year={2015},
  volume={8}
}
BackgroundDespite advances to targeted leishmanicidal chemotherapy, defies around severe toxicity, recent emergence of resistant variants and absence of rational vaccine still persist. This necessitates search and/or progressive validation of accessible medicinal remedies including plant based. The study examined both in vivo and in vitro response of L. major infection to combined therapy of Ricinus communis and Azadirachta indica extracts in BALB/c mice as the mouse model. A comparative study… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani.
TLDR
Since the mechanism of action for the methanolic extract is apparently immunomodulatory, garlic compounds could be purified and tried as complementary medicine in the management of leishmaniases. Expand
The cytotoxic and antileishmanial activity of extracts and fractions of leaves and fruits of Azadirachta indica (A Juss.).
TLDR
The extracts and fractions from leaves and fruits were more effective against amastigotes, and the fractionation increased activity against both promastigote and amastIGotes, enabling us to obtain potentially active fractions with low toxicity. Expand
In vitro and in vivo evaluation of anti-leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection.
TLDR
Ethyl acetate fraction (EAF) alone was found to exhibit leishmanicidal effect validated through cytotoxicity assay and estimated its IC₅₀ to be 52.4 µg/ml on the promastigote stage, and propidium iodide staining of dead cells substantiated the aforementioned activity. Expand
Anti-parasitic activity and cytotoxicity of selected medicinal plants from Kenya.
TLDR
Leishmania major infected macrophages treated with methanol extracts of Suregada zanzibariensis and Aloe nyeriensis var kedongensis and pentostam had infection rates of 28+/-2.11, 30+/-1.22 and 40+/-3.69%, respectively at 1000 microg/ml, indicating better anti-leishmanial activity for the extracts. Expand
Safety and efficacy of Prunus africana and Warburgia ugandensis against induced asthma in BALB/c mice.
TLDR
The results attested that P. africana and W. ugandensis stem bark extracts have anti asthmatic property though there is need for further validation of anti-asthmatic chemical compounds to augment the findings. Expand
Combination therapy using Pentostam and Praziquantel improves lesion healing and parasite resolution in BALB/c mice co-infected with Leishmania major and Schistosoma mansoni
TLDR
Chemotherapy using the first line of treatment for L. major and S. mansoni reduced the lesion size and parasite loads but did not affect the growth response, spleen and liver, and the use of Pentostam or PZQ did not result in any appreciable disease management. Expand
Antileishmanial Activity of an Indole Alkaloid fromPeschiera australis
TLDR
TheLeishmanicidal effects of a chloroform fraction and a purified indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania amazonensis, a causative agent of cutaneous leishmaniasis in the New World are shown. Expand
Essential oil of the leaves of Ricinus communis L.: In vitro cytotoxicity and antimicrobial properties
TLDR
The present study showed the potential antimicrobial and anticarcinogenic properties of the essential oil of Ricinus communis L., indicating the possibilities of its potential use in the formula of natural remedies for the topical treatment of infections. Expand
Activity of antileishmanial agents against amastigotes in human monocyte-derived macrophages and in mouse peritoneal macrophages.
TLDR
The data suggested that the susceptibilities of organisms to Sb within PEC and HM were generally comparable and that either amastigotes or viable promastigote-induced infections could be used to initiate the infection. Expand
Therapeutic effect of subcurative dose praziquantel on Schistosoma mansoni infected mice and resistance to challenge infection after treatment.
TLDR
There was no significant difference in mortality, or parasitological and pathological findings between mice treated with PZQ at the two dosages, however, resistance to challenged worm infection was more sustained in the group treated with subcurative dose PZZ, especially at 3 months after treatment. Expand
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