Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.
@article{Tanigawa2006EvaluationOI, title={Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.}, author={Takahiko Tanigawa and Roland Heinig and Yoshihiro Kuroki and Shun Higuchi}, journal={Drug metabolism and pharmacokinetics}, year={2006}, volume={21 1}, pages={ 61-9 } }
Repinotan is a selective full serotonin receptor agonist at the 5-HT1A subtype which has been studied in phase I and II studies involving over 500 healthy subjects and patients. Repinotan is primarily metabolized by CYP2D6 which is known to be subject to polymorphism and ethnic differences in its quantitative and qualitative expression pattern. In order to investigate the effect of ethnicity on repinotan pharmacokinetics (PK) between a Caucasian and Japanese population and to explain PK…
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