Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.

  title={Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.},
  author={Takahiko Tanigawa and Roland Heinig and Yoshihiro Kuroki and Shun Higuchi},
  journal={Drug metabolism and pharmacokinetics},
  volume={21 1},
Repinotan is a selective full serotonin receptor agonist at the 5-HT1A subtype which has been studied in phase I and II studies involving over 500 healthy subjects and patients. Repinotan is primarily metabolized by CYP2D6 which is known to be subject to polymorphism and ethnic differences in its quantitative and qualitative expression pattern. In order to investigate the effect of ethnicity on repinotan pharmacokinetics (PK) between a Caucasian and Japanese population and to explain PK… 
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A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke: Modified Randomized Exposure Controlled Trial (mRECT)
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A Randomized , Double-Blind , Placebo-Controlled Trial to Evaluate the Efficacy , Safety , Tolerability , and Pharmacokinetic / Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke Modified
Background and Purpose—Repinotan hydrochloride is a serotonin (5-HT)1A receptor full agonist with evidence of neuroprotection in animal models of permanent and transient focal ischemia. The purpose
"A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, tolerability, and pharmacokinetic/ pharmacodynamic effects of a targeted exposure of intravenous repinotan in patients with acute ischemic stroke"
mRECT demonstrated the feasibility of conducting a rigorous trial using a short therapeutic window demanding clinical and radiographic criteria to optimize patient selection and a Point-of-Care test
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The BRAINS Study: Safety, Tolerability, and Dose-finding of Repinotan in Acute Stroke
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  • Medicine
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
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