Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies.

@article{Fang2012EvaluationOI,
  title={Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies.},
  author={Fang Fang and Yanjie Lu and Yue Liang and Jing Zhu and Jiake He and Jianheng Zheng and Ning Li and Yue Tang and Jiabi Zhu and Xijing Chen},
  journal={Die Pharmazie},
  year={2012},
  volume={67 8},
  pages={
          706-11
        }
}
OBJECTIVE To compare the pulmonary absorption characteristics of two insulin solutions-humalog (insulin lispro) and Novolin R (Biosynthetic Human insulin) with in vivo and in vitro methods. METHODS Investigate the pharmacodynamics in Sprague Dawley (SD) rat model (in vivo studies) and permeability across Rana catesbeiana pulmonary membrane (in vitro studies) of Biosynthetic Human insulin (BHI) and insulin lispro (LI) at different doses. RESULTS Both of the insulins could reduce blood… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Formulation strategy and use of excipients in pulmonary drug delivery.

  • International journal of pharmaceutics
  • 2010
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Peptides Are Better Absorbed from the Lung than the Gut in the Rat

  • Pharmaceutical Research
  • 1992
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

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