Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug.

Abstract

The CAP2b neuropeptide family plays an important role in the regulation of the processes of diuresis and/or antidiuresis in a variety of insects. While Manse-CAP2b (pELYAFPRV-NH2) and native CAP2bs elicit diuretic activity in a number of species of flies, native CAP2b sequences have been shown to elicit antidiuretic activity in the kissing bug Rhodnius… (More)
DOI: 10.1016/j.peptides.2012.09.026

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Cite this paper

@article{Nachman2013EvaluationOI, title={Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug.}, author={Ronald J. Nachman and Xiaochen Wang and Felicia A. Etzkorn and Krzysztof Kaczmarek and Janusz Zabrocki and Juan Diego L{\'o}pez and Geoffrey M. Coast}, journal={Peptides}, year={2013}, volume={41}, pages={101-6} }