Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration

@article{Tawfeeq2010EvaluationOI,
  title={Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration},
  author={Mohammad Monir Tawfeeq and Terumasa Suzuki and Keisuke Shimamoto and Hitomi Hayashi and Makoto Shibutani and Kawaminami Mitsumori},
  journal={Archives of Toxicology},
  year={2010},
  volume={85},
  pages={1003-1011}
}
Fenofibrate (FF), a peroxisome proliferator-activated receptor-alpha agonist, has been used as one of the hypolipidemic drugs in man and induces oxidative stress and promotes hepatocarcinogenesis in the liver of rodents. This chemical belongs to a class of non-genotoxic carcinogens, but DNA damage secondary to oxidative stress resulting from reactive oxygen species (ROS) generation is suspected in rodents given this chemical. To examine whether FF has genotoxic potential, partially… CONTINUE READING
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