Evaluation of in vivo efficacy of topical formulations containing soybean extract.

@article{Georgetti2008EvaluationOI,
  title={Evaluation of in vivo efficacy of topical formulations containing soybean extract.},
  author={Sandra Regina Georgetti and R{\'u}bia Casagrande and Waldiceu A Verri and Renata Fonseca Vianna Lopez and Maria Jos{\'e} Vieira Fonseca},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={352 1-2},
  pages={189-96}
}
In the present study it was evaluated the: (i) functional stability of the soybean extract as a raw material and dispersed in two different topical formulations, (ii) skin retention using modified Franz diffusion cells, and (iii) in vivo activity of these formulations to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced hydrogen peroxide (H(2)O(2)) and malondialdehyde (MDA) increases in the skin of hairless mice. The physico-chemical stability was evaluated by pH, globule size and… CONTINUE READING