Evaluation of in vitro enzymatic degradation of various thiomers and cross-linked thiomers.

Abstract

The aim of this study was to examine the biodegradability of thiomers and cross-linked thiomers in comparison with unmodified polymers. Disulfide-cross-linked conjugates were prepared by air oxidation at room temperature. Thiomers were investigated by viscosity measurements and spectrophotometric assays. The influence of different factors on the hydrolysis… (More)

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@article{Kafedjiiski2007EvaluationOI, title={Evaluation of in vitro enzymatic degradation of various thiomers and cross-linked thiomers.}, author={Krum Kafedjiiski and Florian F{\"o}ger and Herbert Hoyer and Andreas Bernkop-Schnuerch and Martin Werle}, journal={Drug development and industrial pharmacy}, year={2007}, volume={33 2}, pages={199-208} }