Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever

@article{Autret2009EvaluationOI,
  title={Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever},
  author={Elisabeth Autret and Jeanne Reboul-Marty and B Henry-Launois and Charlotte Laborde and Soizic Courcier and Jean-marie Goehrs and G Languillat and Robert Launois},
  journal={European Journal of Clinical Pharmacology},
  year={2009},
  volume={51},
  pages={367-371}
}
ObjectiveWe compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6–24 months in an open, randomised study with three parallel groups.MethodsThe main criterion for efficacy was area under the curve (AUC) of percentage temperature reduction. Comfort was assessed on scores depending on general behaviour and degree of relief. General behaviour was assessed on a verbal scale and on a… 

Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study

Ibuprofen at a dose of 10 mg/kg and paracetamol at a doses of 15  mg/kg have equivalent efficacy and tolerability; parental opinion in favor of ib uprofen could be explained by additional benefits of ibUprofen that were not measured in this trial and helped allay their anxiety over the treatment of their child.

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.

Antipyretic effect of ibuprofen and dipyrone in febrile children.

A single oral dose of ibuprofen has a greater antipyretic efficacy than dipyrone, particularly when the fever is high, and both drugs were well tolerated and safe in the short term.

The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection.

AIM To evaluate the antipyretic efficacy and tolerability of dexibuprofen compared with ibuprofen in children with fever caused by upper respiratory tract infection (URTI). METHODS The study

EVALUATION OF EFFICACY AND TOLERABILITY OF ACETAMINOPHEN (PARACETAMOL) AND MEFENAMIC ACID AS ANTIPYRETIC IN PEDIATRIC PATIENTS WITH FEBRILE ILLNESS: A COMPARATIVE STUDY.

Mefenamic acid was found to be more effective and equally tolerable than par acetamol as an antipyretic in pediatric patients with febrile illness and can be the best alternative to paracetamol.

The effect of paracetamol ( acetaminophen ) and ibuprofen on body temperature in acute stroke : Protocol for a phase II double-blind randomised placebo-controlled trial [ ISRCTN 98608690 ]

The effects of high-dose paracetamol and ibuprofen on body temperature in patients with acute ischaemic stroke are studied and the safety of these treatments is studied to study the safety and pharmacological reduction of temperature.

Use of ibuprofen in paediatric populations.

In the paediatric population, ibuprofen and paracetamol are both commonly used over-the-counter (OTC) drugs for the management of fever or mild-to-moderate pain associated with sore throat,

Recent Advances in Pediatric Use of Oral Paracetamol in Fever and Pain Management

Clinical evidence qualifies paracetamol 15 mg/kg a safe and effective option for treatment of pain and fever in children and it is indicated for use in children of all ages.

Evaluation of Efficacy and Tolerability of Acetaminophen (Paracetamol) and Mefenamic Acid and Paracetamol Combination as Antipyretic In Pediatric Patients with Febrile Illness: A Comparative Study

Mefenamic acid par acetamol combination was found to be more effective and equally tolerable than paracetamol as an antipyretic in pediatric patients with febrile illness and can be the best alternative to paracetAMol.

Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial.

Paracetamol and ibuprofen together was the cheapest option for the NHS due to the lower use of health-care services and cheapest for parents because the lowerUse of health care services resulted in personal saving on travel costs and less time off work.
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References

SHOWING 1-10 OF 19 REFERENCES

Efficacy of ibuprofen in pediatric patients with fever.

The authors studied the efficacy of ibuprofen in 56 infants and children with rectal temperature greater than or equal to 38.3 degrees C, using a double-blind randomized placebo-controlled design and found the duration of action was longer for ib uprofen 10 mg/kg than 5mg/kg.

Antipyretic efficacy of ibuprofen vs acetaminophen.

Ibuprofen is a potent antipyretic agent and is a safe alternative for the selected febrile child who may benefit from antipYretic medication but who either cannot take or does not achieve satisfactory antipyresis with acetaminophen.

Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children.

Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics

In conclusion, significant antipyretic activity, good tolerability and its availability as a syrup make ibuprofen an effective means of fever control in children.

Comparison of multidose ibuprofen and acetaminophen therapy in febrile children.

While further confirmatory studies are needed, ibuprofen liquid and acetaminophen elixir administered every 6 hours for 24 to 48 hours appeared to be most effective in reducing fever.

Ibuprofen, acetaminophen, and placebo treatment of febrile children

Ibuprofen suspension may be a safe and effective antipyretic in children with fever and acetaminophen elixir was well tolerated and more effective than placebo for fever control.

Ibuprofen levels in serum and synovial fluid.

Ibuprofen concentrations fluctuated far less in synovial fluid than in serum, and peak levels were reached 5-6 hours after drug intake, and thereafter, the levels declined slowly but 12 hours later were still higher than in Serum.

Aspirin and Reye's Syndrome: The Change in Prescribing Habits of Health Professionals

This study was conducted to determine whether the possible association between aspirin and Reye's syndrome in viral influenza and chicken pox deterred pediatricians and pharmacists in a large American city from prescribing or recommending aspirin to their pediatric patients suffering from other causes of fever or pain.

Aspirin and Reye's syndrome.

  • W. P. Glezen
  • Medicine
    American journal of diseases of children
  • 1982
A series of case-control studies have been reported that suggest that the administration of aspirin to children during the prodromal viral infection increases the risk for development of Reye's syndrome.

National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985.

Pharmaceutical marketing research data suggest sharp decreases in the use and purchase of children's aspirin between 1980 and 1985 that appear to correspond to the decrease in reporting of Reye syndrome cases.