Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever

  title={Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever},
  author={E. Autret and J. Reboul-Marty and B. Henry-Launois and C. Laborde and S. Courcier and J. Goehrs and G. Languillat and R. Launois},
  journal={European Journal of Clinical Pharmacology},
ObjectiveWe compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6–24 months in an open, randomised study with three parallel groups.MethodsThe main criterion for efficacy was area under the curve (AUC) of percentage temperature reduction. Comfort was assessed on scores depending on general behaviour and degree of relief. General behaviour was assessed on a verbal scale and on a… Expand

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