Evaluation of hydrophilic matrix tablets based on Carbopol(®) 971P and low-viscosity sodium alginate for pH-independent controlled drug release.

@article{AlZoubi2011EvaluationOH,
  title={Evaluation of hydrophilic matrix tablets based on Carbopol(®) 971P and low-viscosity sodium alginate for pH-independent controlled drug release.},
  author={Nizar M Al-Zoubi and Hatim S. Alkhatib and Wasfy M. Obeidat},
  journal={Drug development and industrial pharmacy},
  year={2011},
  volume={37 7},
  pages={798-808}
}
BACKGROUND The aim of this study was to evaluate matrix tablets containing different ratios of Carbopol(®) 971P (CP) to low-viscosity sodium alginate (SA) and assess their suitability for pH-independent controlled drug release. METHODS Two processing methods (physical mixing, PM and spray-drying, SD) were applied before compaction and the release from corresponding matrices was compared. The release from CP-SA PM matrices was also investigated using three model drugs (paracetamol, salicylic… CONTINUE READING
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Formulating Controlled Release Tablets and Capsules with Carbopol ® Polymers

  • J Moore, H Flanner
  • 2008

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