Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.

@article{Patel1992EvaluationOH,
  title={Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.},
  author={M. Patel and I. S. Kayani and W. Templeton and G. Mellor and E. Thomas and K. Brocklehurst},
  journal={The Biochemical journal},
  year={1992},
  volume={287 ( Pt 3)},
  pages={
          881-9
        }
}
1. 2-(N'-Acetyl-D-phenylalanyl)hydroxyethyl 2'-pyridyl disulphide (compound IV) (m.p. 59 degrees C; [alpha]D20 -6.6 degrees (c 1.2 in methanol)) was synthesized. 2. The results of a study of the pH-dependence of the second-order rate constant (k) for its reaction with the catalytic-site thiol group (Cys-25) of papain (EC 3.4.22.2) together with analogous kinetic data for the reactions of related time-dependent inhibitors, notably the L-enantiomer of compound (IV) (compound III) and the L- and D… Expand
Catalytic mechanism in papain family of cysteine peptidases.
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