Evaluation of hybrid and non-hybrid methods for de novo assembly of nanopore reads

@article{Sovic2016EvaluationOH,
  title={Evaluation of hybrid and non-hybrid methods for de novo assembly of nanopore reads},
  author={Ivan Sovic and Kresimir Krizanovic and Karolj Skala and Mile {\vS}iki{\'c}},
  journal={Bioinformatics},
  year={2016},
  volume={32 17},
  pages={2582-9}
}
MOTIVATION Recent emergence of nanopore sequencing technology set a challenge for established assembly methods. In this work, we assessed how existing hybrid and non-hybrid de novo assembly methods perform on long and error prone nanopore reads. RESULTS We benchmarked five non-hybrid (in terms of both error correction and scaffolding) assembly pipelines as well as two hybrid assemblers which use third generation sequencing data to scaffold Illumina assemblies. Tests were performed on several… CONTINUE READING
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