Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy.

@article{Sei1996EvaluationOH,
  title={Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy.},
  author={Shizuko Sei and Sean Stewart and Melissa Farley and Brigitta U. M{\"u}ller and James R Lane and Merlin L. Robb and Pim Y Brouwers and Philip A. Pizzo},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={174 6},
  pages={1200-6}
}
The amount of human immunodeficiency virus (HIV) type 1 RNA and the presence of a codon 215 mutation indicative of zidovudine resistance were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n = 25; median, 430 copies/mL; range, 0-2.2 x 10(5) copies/mL) followed by the moderately encephalopathic (n = 7; median, 330; range, 0-1130) and nonencephalopathic groups (n = 9; median… CONTINUE READING