Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient.

@article{Shigehiro2016EvaluationOG,
  title={Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient.},
  author={Tsukasa Shigehiro and Wenjia Zhai and Arun Vaidyanath and Junko Masuda and Akifumi Mizutani and Tomonari Kasai and Hiroshi Murakami and Hiroki Hamada and David S. Salomon and Katsuhiko Mikuni and Yuhki Seno and Tadakatsu Mandai and Masaharu Seno},
  journal={Journal of microencapsulation},
  year={2016},
  volume={33 2},
  pages={172-82}
}
Docetaxel comprises one of the most effective anti-cancer drugs despite of serious side effects. Liposomes encapsulation is practically feasible to deliver the drug. However, due to the significant hydrophobicity, docetaxel will be integrated into the lipid bilayer resulting in poor encapsulation capacity. Here, we evaluated a remote loading strategy using… CONTINUE READING