Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.

@article{Yang2008EvaluationOG,
  title={Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.},
  author={Hushan Yang and Colin P. N. Dinney and Yuanqing Ye and Yong Zhu and Herbert Barton Grossman and X ianchao Wu},
  journal={Cancer research},
  year={2008},
  volume={68 7},
  pages={2530-7}
}
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads to enhanced tumorigenesis, the effect of common genetic variants of miRNA-related genes on cancer predisposition is unclear. To better understand this effect, we genotyped 41 single-nucleotide polymorphisms (SNP) from 24 miRNA-related genes in a case-control study conducted in 746 Caucasian patients with… CONTINUE READING
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