Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study

@inproceedings{Piccolo2009EvaluationOG,
  title={Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study},
  author={Stephen R. Piccolo and Ryan Abo and Kristina Allen-Brady and Nicola J. Camp and Stacey Knight and Jeffrey L Anderson and Benjamin D. Horne},
  booktitle={BMC proceedings},
  year={2009}
}
BACKGROUND Multiple single-nucleotide polymorphisms have been associated with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels. In this paper, we evaluate a weighted and an unweighted approach for estimating the combined effect of multiple markers (using genotypes and haplotypes) on lipid levels for a given individual. METHODS Using data from the Framingham Heart Study SHARe genome-wide association study, we tested genome… CONTINUE READING
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