Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

Abstract

Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal absorption for difficult-to-formulate, poorly soluble drug candidates based on a design approach that includes (1) converting the drug into a high energy or rapidly dissolving system which presents a supersaturated solution to the gastrointestinal environment and (2) dosage… (More)
DOI: 10.1016/j.ijpharm.2012.11.026

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