• Medicine
  • Published in Infection and immunity 1995

Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters.

@article{Torres1995EvaluationOF,
  title={Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters.},
  author={Janet Torres and David Maxwell Lyerly and Jason Eric Hill and Thomas P. Monath},
  journal={Infection and immunity},
  year={1995},
  volume={63 12},
  pages={
          4619-27
        }
}
Clostridium difficile produces toxins that cause inflammation, necrosis, and fluid in the intestine and is the most important cause of nosocomial antibiotic-associated diarrhea and colitis. We evaluated C. difficile antigens as vaccines to protect against systemic and intestinal disease in a hamster model of clindamycin colitis. Formalin-inactivated culture filtrates from a highly toxigenic strain were administered by mucosal routes (intranasal, intragastric, and rectal) with cholera toxin as a… CONTINUE READING

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