Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approach.


Incorporation of fluorine in a drug can dramatically affect its metabolism and methods to assess the effect of fluorine substitution on drug metabolism are required for effective drug design. Employing a previously developed chemical-microbial method the metabolism of a series of fluorinated biphenyl ethers was determined. The substrates were synthesized… (More)
DOI: 10.1016/j.bmcl.2016.03.053


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