Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans.

@article{Buckham2010EvaluationOF,
  title={Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans.},
  author={Theresa A Buckham and Amy-Jayne McKnight and David Benevente and Aisling E. Courtney and Christopher C. Patterson and M. A. Simmonds and Steven B. Gough and Derek Middleton and Richard J Borrows and Alexander Peter Maxwell},
  journal={American journal of nephrology},
  year={2010},
  volume={32 2},
  pages={103-8}
}
BACKGROUND Genetic variation within interleukin genes has been reported to be associated with end-stage renal disease (ESRD). These findings have not been consistently replicated. No study has yet reported the comprehensive investigation of IL1A, IL1B, IL1RN,IL6 and IL10 genes. METHODS 664 kidney transplant recipients (cases) and 577 kidney donors (controls) were genotyped to establish if common variants in interleukin genes are associated with ESRD. Single nucleotide polymorphism (SNP… CONTINUE READING

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