Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in vivo assays in mice.

@article{Wiley2016EvaluationOF,
  title={Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in vivo assays in mice.},
  author={Jenny L Wiley and Timothy W. Lefever and Julie A Marusich and Megan Grabenauer and Katherine N. Moore and John W. Huffman and Brian F. Thomas},
  journal={Neuropharmacology},
  year={2016},
  volume={110 Pt A},
  pages={143-153}
}
Anecdotal reports suggest that abused synthetic cannabinoids produce cannabis-like "highs," but some of their effects may also differ from traditional cannabinoids such as Δ(9)-tetrahydrocannabinol (THC). This study examined the binding affinities of first-generation indole-derived synthetic cannabinoids at cannabinoid and noncannabinoid receptors and their effects in a functional observational battery (FOB) and drug discrimination in mice. All seven compounds, except JWH-391, had favorable… CONTINUE READING
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