Evaluation of factors affecting gastrointestinal absorption of a novel anticoagulant FX-93 for development of oral formulation.

Abstract

To find out factors causing the low bioavailability of FX-93, a novel anticoagulant, its solubility, membrane permeability, and the effect of bile salt on the absorption of FX-93 were investigated. The solubility of FX-93 under physiological conditions ranged from 0.3 to 18.3 mg/mL and the dose number was calculated to be 0.02-0.27, suggesting that the… (More)
DOI: 10.1002/jps.23116

Topics

Cite this paper

@article{Takemura2012EvaluationOF, title={Evaluation of factors affecting gastrointestinal absorption of a novel anticoagulant FX-93 for development of oral formulation.}, author={Shigeo Takemura and Hiromu Kondo and Kenichi Suzumura and Ken-ichi Ogawara and Shunsuke J Watanabe and Kazuhiro Sako and Kazutaka Higaki}, journal={Journal of pharmaceutical sciences}, year={2012}, volume={101 6}, pages={2134-42} }