Evaluation of eye and skin irritation of arginine-derivative surfactants using different in vitro endpoints as alternatives to the in vivo assays.

@article{Martinez2006EvaluationOE,
  title={Evaluation of eye and skin irritation of arginine-derivative surfactants using different in vitro endpoints as alternatives to the in vivo assays.},
  author={V. Martinez and Emanuella Corsini and Montserrat Mitjans and Aurora Pinazo and Mar{\'i}a Pilar Vinardell},
  journal={Toxicology letters},
  year={2006},
  volume={164 3},
  pages={259-67}
}
Arginine-derivative surfactants constitute a novel class of surfactants, which can be regarded as an alternative to conventional surfactants. Prior to human exposure, it is necessary to assess their irritation potential. The classical in vivo evaluation of the irritancy potential via the Draize test has been extensively criticized. In that regard, a great number of in vitro alternatives have been developed. Erythrocytes were chosen as the target cells for eye irritation assessment and hemolysis… CONTINUE READING

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