Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

@article{Liu2001EvaluationOE,
  title={Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.},
  author={J. Liu and J. Burdette and H. Xu and C. Gu and R. V. van Breemen and K. Bhat and N. Booth and A. Constantinou and J. Pezzuto and H. Fong and N. Farnsworth and J. Bolton},
  journal={Journal of agricultural and food chemistry},
  year={2001},
  volume={49 5},
  pages={
          2472-9
        }
}
Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus L.), and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta). With cultured Ishikawa (endometrial) cells, red clover and hops exhibited estrogenic activity as indicated by induction of alkaline phosphatase (AP… Expand
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