Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

@article{Liu2001EvaluationOE,
  title={Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.},
  author={Jian Liu and Joanna E. Burdette and H H Xu and C Gu and Richard B. van Breemen and Krishna P Bhat and Nancy Lynn Booth and Andreas Constantinou and John M. Pezzuto and Harry H. S. Fong and N. R. Farnsworth and Judy L. Bolton},
  journal={Journal of agricultural and food chemistry},
  year={2001},
  volume={49 5},
  pages={
          2472-9
        }
}
Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus L.), and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta). With cultured Ishikawa (endometrial) cells, red clover and hops exhibited estrogenic activity as indicated by induction of alkaline phosphatase (AP… 

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