Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

@article{Liu2001EvaluationOE,
  title={Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.},
  author={Jian Liu and Joanna E. Burdette and H H Xu and C Gu and Richard B. van Breemen and Krishna P Bhat and Nancy Lynn Booth and Andreas Constantinou and John M. Pezzuto and Harry H. S. Fong and N. R. Farnsworth and Judy L. Bolton},
  journal={Journal of agricultural and food chemistry},
  year={2001},
  volume={49 5},
  pages={
          2472-9
        }
}
Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus L.), and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta). With cultured Ishikawa (endometrial) cells, red clover and hops exhibited estrogenic activity as indicated by induction of alkaline phosphatase (AP… 
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Hop and red clover extracts as well as 8-PN up-regulated progesterone receptor (PR) mRNA in the Ishikawa cell line could be attractive for the development as herbal dietary supplements to alleviate menopause-associated symptoms.
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TLDR
Results show that several legumes are a source of phytoestrogens with high levels of estrogenic activity, and the active components in kudzu root extract were determined to be the isoflavones puerarin, daidzin, genistin,daidzein, and genistein.
In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms.
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Ethanolic Extract of Papaya (Carica papaya) Leaf Exhibits Estrogenic Effects In Vivo and In Silico
The menopause women have the low level of estrogen in the body. The lack of estrogen changes physiological function in women’s body that affects in health condition. Carica papaya L. leaf contains…
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