Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.

  title={Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.},
  author={Rakhee Kar and P Mishra and Hara Prasad P Pati},
  journal={International journal of laboratory hematology},
  volume={32 1 Pt 2},
A flow cytometry-based test using eosin-5-maleimide (EMA) dye was used for diagnosis of hereditary spherocytosis (HS). The mean fluorescence intensiy (MFI) of EMA tagged erythrocytes is lower in HS than that in other hemolytic and nonhemolytic anemias. We enrolled 114 subjects comprising 20 confirmed HS, 20 suspected HS/hemolytic anemia (HA), 20 normal controls, 20 other hemolytic anemias [13 autoimmune hemolytic anemia, three congenital dyserythropoietic anemia (CDA), one pyruvate kinase… CONTINUE READING


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