Evaluation of early reperfusion and i.v. tPA therapy using diffusion- and perfusion-weighted MRI.

@article{Marks1999EvaluationOE,
  title={Evaluation of early reperfusion and i.v. tPA therapy using diffusion- and perfusion-weighted MRI.},
  author={M P Marks and David C. Tong and Christian Beaulieu and Gregory W. Albers and Alex J. de Crespigny and Michael E. Moseley},
  journal={Neurology},
  year={1999},
  volume={52 9},
  pages={1792-8}
}
OBJECTIVE To characterize the effects of recombinant tissue plasminogen activator (rt-PA) therapy and early reperfusion on diffusion-weighted (DWI) and perfusion-weighted imaging (PWI) changes observed following acute ischemic injury. METHODS Twelve patients were evaluated prospectively using echo planar DWI and bolus tracking PWI. Six patients received i.v. rt-PA 0.9 mg/kg and were compared with six patients who did not. Patients receiving rt-PA were initially imaged (T1) 3 to 5 hours… CONTINUE READING

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