Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys.


Given concern about potential embryo-fetal harm following seminal exposure to drugs with teratogenic potential, pharmaceutical companies use theoretical calculations to estimate seminal concentrations, maternal exposure, and distribution across the placenta to the embryo-fetal compartment for risk assessment. However, it is plausible that there are… (More)
DOI: 10.1016/j.reprotox.2015.10.013


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