Evaluation of drug physical form during granulation, tabletting and storage.

@article{Williams2004EvaluationOD,
  title={Evaluation of drug physical form during granulation, tabletting and storage.},
  author={Adrian C. Williams and V. Brett Cooper and Lisa Cheryl Thomas and Letecia J Griffith and Catherine R. Petts and Steven W. Booth},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={275 1-2},
  pages={
          29-39
        }
}
An active pharmaceutical ingredient (API) was found to dissociate from the highly crystalline hydrochloride form to the amorphous free base form, with consequent alterations to tablet properties. Here, a wet granulation manufacturing process has been investigated using in situ Fourier transform (FT)-Raman spectroscopic analyses of granules and tablets prepared with different granulating fluids and under different manufacturing conditions. Dosage form stability under a range of storage stresses… CONTINUE READING

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