Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model

@article{Kim2018EvaluationOD,
  title={Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model},
  author={Jinil Kim and S. Choi and S. J. Ham and Y. C. Cho and Seul-I Lee and Jeeheon Kang and D. Woo and W. S. Lee and Jin-San Yoo and Kyung Won Kim and Yoonseok Choi},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
Purpose Targeting of vascular endothelial growth factor receptors (VEGFRs) has potential anti-angiogenic effects because VEGFR-2 is the major signaling regulator of VEGF/VEGFR pathways. We aimed to elucidate the drug mechanism and anti-tumor efficacy of TTAC-0001, a novel, fully human anti-VEGFR-2/KDR monoclonal antibody, in mouse orthotopic breast cancer model using multi-modal bioimaging. Materials and methods We used orthotopic xenograft tumor model in which human breast cancer cells (MDA-MB… Expand
1 Citations

References

SHOWING 1-10 OF 42 REFERENCES
Novel anti-angiogenic therapeutic strategies in colorectal cancer
Imaging and oncologic drug development.
...
1
2
3
4
5
...