Evaluation of different ways of presenting LipL32 to the immune system with the aim of developing a recombinant vaccine against leptospirosis.

@article{Seixas2007EvaluationOD,
  title={Evaluation of different ways of presenting LipL32 to the immune system with the aim of developing a recombinant vaccine against leptospirosis.},
  author={Fabiana K{\"o}mmling Seixas and Cl{\'a}udia Pinho Hartleben Fernandes and Daiane Drawanz Hartwig and Fabr{\'i}cio Rochedo Conceiç{\~a}o and Jos{\'e} Ant{\^o}nio Guimar{\~a}es Aleixo and Odir Antonio Dellagostin},
  journal={Canadian journal of microbiology},
  year={2007},
  volume={53 4},
  pages={
          472-9
        }
}
Leptospirosis, caused by bacteria of the genus Leptospira, is a direct zoonosis with wide geographical distribution. The implications in terms of public health and the economical losses caused by leptospirosis justify the use of a vaccine against Leptospira in human or animal populations at risk. In this study, we used the external membrane protein LipL32 as a model antigen, as it is highly immunogenic. The LipL32 coding sequence was cloned into several expression vectors: (i) pTarget, to… CONTINUE READING
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