Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial.

@article{Kirkland2010EvaluationOD,
  title={Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial.},
  author={David J. Kirkland},
  journal={Mutation research},
  year={2010},
  volume={702 2},
  pages={
          139-47
        }
}

• David J. Kirkland
• Published in Mutation research 2010
• DOI:10.1016/j.mrgentox.2010.02.001

This paper summarises the data for 14 different chemicals tested for induction of micronuclei (MN) in 5 different cell types across 12 different laboratories. All 14 chemicals induced biologically and statistically significant increases in MN frequency in the different cell types (L5178Y, TK6, CHO, CHL, V79) in the absence of cytochalasin B at or below target range toxicity (55+5%) irrespective of whether relative cell count (RCC), relative increase in cell count (RICC) or relative population… CONTINUE READING

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