Evaluation of diazepam-molecularly imprinted microspheres for the separation of diazepam and its main metabolite from body fluid samples.

@article{Su2012EvaluationOD,
  title={Evaluation of diazepam-molecularly imprinted microspheres for the separation of diazepam and its main metabolite from body fluid samples.},
  author={Qiaoling Su and Chuying Zeng and Youwen Tang and D. Finlow and Min Cao},
  journal={Journal of chromatographic science},
  year={2012},
  volume={50 7},
  pages={
          608-14
        }
}
Molecularly imprinted microspheres (MIMs) for the drug diazepam and its main metabolite (nordiazepam) were prepared and used to separate the two species from urine and serum samples via molecularly imprinted solid-phase extraction. The specific binding capacity for diazepam was determined to be 1.97 mg/g, resulting in an imprinting factor of 5.8. The MIMs exhibit highly selective binding affinity for tricyclic benzodiazepines. Water-acetonitrile-acetone mixtures were used as the washing solvent… Expand
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