Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.

@article{Dartel2011EvaluationOD,
  title={Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.},
  author={Dorien A.M. van Dartel and Jeroen L. A. Pennings and Liset J J de la Fonteyne and Karen J. J. Brauers and Sandra M. H. Claessen and Joost H M van Delft and Jos Kleinjans and Aldert H. Piersma},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={119 1},
  pages={126-34}
}
The murine embryonic stem cell test (EST) is an alternative testing method designed to assess potential developmental toxicity of compounds. The implementation of transcriptomics in the EST has been shown to reduce the culture duration and improve endpoint evaluation and is expected to result in an enhanced predictability and definition of the applicability domain. We evaluated the identification of developmental toxicity in the EST using two gene sets ("Van_Dartel_heartdiff_24h" and "EST… CONTINUE READING
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Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells

  • A. De Smedt, M. Steemans, +5 authors P. Vanparys
  • Toxicol. In Vitro
  • 2008
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