Evaluation of deuterated 18F- and 11C-labeled choline analogs for cancer detection by positron emission tomography.


PURPOSE (11)C-Choline-positron emission tomography (PET) has been exploited to detect the aberrant choline metabolism in tumors. Radiolabeled choline uptake within the imaging time is primarily a function of transport, phosphorylation, and oxidation. Rapid choline oxidation, however, complicates interpretation of PET data. In this study, we investigated the… (More)
DOI: 10.1158/1078-0432.CCR-11-2462