Evaluation of designs for clinical trials of neuroprotective agents in head injury. European Brain Injury Consortium.

@article{Machado1999EvaluationOD,
  title={Evaluation of designs for clinical trials of neuroprotective agents in head injury. European Brain Injury Consortium.},
  author={Stella G Machado and Gordon D. Murray and Graham M. Teasdale},
  journal={Journal of neurotrauma},
  year={1999},
  volume={16 12},
  pages={1131-8}
}
In a study involving the statistical modeling of potential head injury trials, we explore approaches to trial design that could enhance their power to detect treatment-related effects on clinical outcome. The study uses a survey organized by the European Brain Injury Consortium of over 1,000 head-injured patients to characterize the population from which trial participants can be selected. A variety of models are postulated for the effects of "neuroprotective" treatment on outcome, and their… CONTINUE READING

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