Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model.

@article{TorneroVelez2010EvaluationOD,
  title={Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model.},
  author={Rogelio Tornero-Velez and Ahmad Mirfazaelian and Kyu-Bong Kim and Sathanandam S. Anand and Hyo Jung Kim and Wendy T Haines and James V. Bruckner and Jeffrey Fisher},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={244 2},
  pages={208-17}
}
Immature rats are more susceptible than adults to the acute neurotoxicity of pyrethroid insecticides like deltamethrin (DLM). A companion kinetics study (Kim et al., in press) revealed that blood and brain levels of the neuroactive parent compound were inversely related to age in rats 10, 21, 40 and 90 days old. The objective of the current study was to… CONTINUE READING