Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs).

@article{Yim2017EvaluationOD,
  title={Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs).},
  author={Juwon Yim and Jordan R. Smith and Nivedita B Singh and Seth A Rice and Kyle C Stamper and Cristina Garc{\'i}a de la M{\`a}ria and Arnold S. Bayer and Nagendra N. Mishra and Jose M Mir{\'o} and T. T. T. Tran and C{\'e}sar A. Arias and Paul M Sullam and Michael Joseph Rybak},
  journal={The Journal of antimicrobial chemotherapy},
  year={2017},
  volume={72 8},
  pages={
          2290-2296
        }
}
Objectives Among viridans group streptococcal infective endocarditis (IE), the Streptococcus mitis group is the most common aetiological organism. Treatment of IE caused by the S. mitis group is challenging due to the high frequency of β-lactam resistance, drug allergy and intolerability of mainstay antimicrobial agents such as vancomycin or gentamicin. Daptomycin has been suggested as an alternative therapeutic option in these scenarios based on its excellent susceptibility profile against S… CONTINUE READING
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