Evaluation of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, 18F-fallypride in nonhuman primates using positron emission tomography.

@article{Mukherjee1997EvaluationOD,
  title={Evaluation of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, 18F-fallypride in nonhuman primates using positron emission tomography.},
  author={Jogeshwar Mukherjee and Zheng Yu Yang and Robert Lew and Timothy G. Brown and S Kronmal and Max D. Cooper and Lewis S. Seiden},
  journal={Synapse},
  year={1997},
  volume={27 1},
  pages={1-13}
}
We have investigated the ability of dopamine to compete with the binding of the high affinity dopamine D2 receptor positron emission tomography (PET) radioligand, 18F-fallypride. In vitro dissociation of 18F-fallypride with dopamine in rat striatal homogenates exhibited a dissociation rate, k(off), of 1.76 x 10(-2) min(-1) while the association rate constant, k(on), was found to be 5.30 x 10(8) M(-1) min(-1). This resulted in a dissociation constant, K(D) of 33 pM for 18F-fallypride. For in… CONTINUE READING