Evaluation of cytokine and chemokine response elicited by Rv2204c and Rv0753c to detect latent tuberculosis infection.

@article{Pathakumari2015EvaluationOC,
  title={Evaluation of cytokine and chemokine response elicited by Rv2204c and Rv0753c to detect latent tuberculosis infection.},
  author={Balaji Pathakumari and Maddineni Prabhavathi and A. Mani Muthu Raja},
  journal={Cytokine},
  year={2015},
  volume={76 2},
  pages={
          496-504
        }
}
Latent TB infection (LTBI) is one of the major contributing factors for the high incidence of TB in India that in turn significantly contributes to the pool of active TB. Hence, identification and treatment of LTBI is of utmost importance. Currently, no specific diagnostic test is available for LTBI. Earlier, in our immunoproteomic analysis, we identified Rv2204c and Rv0753c protein-containing fractions induced significantly higher interferon-gamma (IFN-γ) response in LTBI than in active TB. In… CONTINUE READING
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