Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats.

@article{Agarwal2010EvaluationOC,
  title={Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats.},
  author={Rakhi Agarwal and Sheikh Raisuddin and Shikha Tewari and Sudhir Goel and Rajendra Behari Raizada and Jai Raj Behari},
  journal={Journal of biochemical and molecular toxicology},
  year={2010},
  volume={24 2},
  pages={123-35}
}
To evaluate the effect of pre- or posttreatment of selenium (6 micromol/kg b.w., single intraperitoneal injection) in mercury intoxication, rats were exposed to mercury (12 micromol/kg b.w., single intraperitoneal injection). Exposure to mercury resulted in induced oxidative stress in liver, kidney, and brain tissues. Marked changes in serum biochemical parameters together with alterations in histopathology and an induction in metallothionein-I and metallothionein-II mRNA expression in the… CONTINUE READING
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