Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis.

@article{Kuehn2011EvaluationOC,
  title={Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis.},
  author={Christian Kuehn and Claudia Disqu{\'e} and Helge M{\"u}hl and Peter Orszag and Meike Stiesch and Axel Haverich},
  journal={Journal of clinical microbiology},
  year={2011},
  volume={49 8},
  pages={2919-23}
}
Two new commercially available universal rRNA gene PCR plus sequencing tests, SepsiTest and universal microbe detection (UMD; Molzym, Bremen, Germany), were evaluated using blood specimens and heart valves from 30 patients with suspected infectious endocarditis (IE). The sensitivity of PCR (85%) was nearly twice as high as that of culture (45%), which in 10/20 IE cases presumably stayed negative as a consequence of growth inhibition of the pathogens by antibiotics. Further, PCR provided the… CONTINUE READING
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New technology for rapid molecular diagnosis of bloodstream infections

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