Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs.

@article{Boria2004EvaluationOC,
  title={Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs.},
  author={Pedro A Boria and Daryl J. Murry and Peter F Bennett and Nita W. Glickman and Paul W. Snyder and Brenna L Merkel and Deborah L Schlittler and Anthony J. Mutsaers and Rose Maria Thomas and Deborah W Knapp},
  journal={Journal of the American Veterinary Medical Association},
  year={2004},
  volume={224 3},
  pages={388-94}
}
OBJECTIVE To determine the maximum tolerated dose (MTD) of cisplatin administered with piroxicam, the antitumor activity and toxicity of cisplatin combined with piroxicam in dogs with oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC), and the effects of piroxicam on the pharmacokinetics of cisplatin in dogs with tumors. DESIGN Prospective nonrandomized clinical trial. ANIMALS 25 dogs. PROCEDURE Dogs were treated with a combination of cisplatin (escalating dose with 6… CONTINUE READING
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