Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit.

@article{GilBea2005EvaluationOC,
  title={Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit.},
  author={Francisco J Gil-Bea and Monica Garcia-Alloza and Jon Dom{\'i}nguez and Beatriz Marcos and Mar{\'i}a J Ram{\'i}rez},
  journal={Neuroscience letters},
  year={2005},
  volume={375 1},
  pages={37-41}
}
Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have been closely related to cholinergic deficits. We have compared different markers of cholinergic function to assess the best biomarker of cognitive deficits associated to cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh) levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all reduced compared to controls. Both ChAT and AChE activity… CONTINUE READING