Evaluation of chick embryo neural retinal cell culture as a screen for developmental toxicants.

@article{Daston1995EvaluationOC,
  title={Evaluation of chick embryo neural retinal cell culture as a screen for developmental toxicants.},
  author={George P. Daston and Danica Baines and Emily W. Elmore and Mary Pat Fitzgerald and Sanjay Bhardwaj Sharma},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1995},
  volume={26 2},
  pages={
          203-10
        }
}
This paper describes a study to evaluate the concordance with in vivo results of an in vitro screen for developmental toxicants. The screen is a primary culture of chick embryo neural retina cells (CERC) which undergo processes of cell-cell recognition and interaction, growth, and differentiation over a 7-day culture period. Each of these developmentally significant events is measured separately as formation of multicellular aggregates, protein content, and glutamine synthetase activity… CONTINUE READING
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