Evaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-a.

@article{Ocakoglu2015EvaluationOC,
  title={Evaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-a.},
  author={Kasim Ocakoglu and {\"O}zge Er and Fatma Yurt Lambrecht and Sunde Yılmaz S{\"u}sl{\"u}er and Cagla Kayabasi and Cumhur G{\"u}nd{\"u}z and Osman Yılmaz},
  journal={Journal of drug targeting},
  year={2015},
  volume={23 1},
  pages={89-95}
}
The biological potential of a synthetic copper chlorophyll derivative was investigated via in vivo and in vitro experiments. The Cu-chlorophyll derivative photosensitizer (Cu-PH-A) was labeled with (131)I with high efficiency (92.9 ± 4.2%) using the iodogen method. Cell culture studies were performed with the MCF-7 and MDAH-2774 cell lines after radiolabeling. The photosensitizing activity of Cu-PH-A was more effective in MDAH-2774 cells than in MCF-7 cells at a concentration of 50 μM. When the… CONTINUE READING