Evaluation of backbone-cyclized HER2-binding 2-helix affibody molecule for in vivo molecular imaging.

@article{Honarvar2013EvaluationOB,
  title={Evaluation of backbone-cyclized HER2-binding 2-helix affibody molecule for in vivo molecular imaging.},
  author={Hadis Honarvar and Nima Jokilaakso and K. Kristoffer Andersson and Jennie Malmberg and Daniel Rosik and Anna Orlova and Amelie Eriksson Karlstr{\"o}m and Vladimir Tolmachev and Peter J{\"a}rver},
  journal={Nuclear medicine and biology},
  year={2013},
  volume={40 3},
  pages={
          378-86
        }
}
INTRODUCTION Affibody molecules, small scaffold proteins, have demonstrated an appreciable potential as imaging probes. Affibody molecules are composed of three alpha-helices. Helices 1 and 2 are involved in molecular recognition, while helix 3 provides stability. The size of Affibody molecules can be reduced by omitting the third alpha-helix and cross-linking the two remaining, providing a smaller molecule with better extravasation and quicker clearance of unbound tracer. The goal of this… CONTINUE READING
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