Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens

@article{GeelhaarKarsch2013EvaluationOA,
  title={Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens},
  author={Anika Geelhaar-Karsch and Katina Schinnerling and Kristina Conrad and Julian Friebel and Kristina Allers and Thomas Schneider and Verena Moos},
  journal={Inflammation Research},
  year={2013},
  volume={62},
  pages={865-869}
}
Macrophage heterogeneity reflects their plasticity in response to environmental stimuli. Usually human macrophages are characterized by analysis of surface molecules or cytokine expression while functional assays are established in the mouse system but lacking for various human specimens. To evaluate the value of analysis of arginine metabolism for characterization of human macrophage differentiation, we analyzed nitrite production and arginase activity in plasma, duodenal biopsies, and in… CONTINUE READING

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