Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes.

  title={Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes.},
  author={Kae Shimazaki and Koichi Ohshima and Junji Suzumiya and Chika Kawasaki and Masahiro Kikuchi},
  journal={British journal of haematology},
  volume={110 3},
The myelodysplastic syndromes (MDS) are a group of disorders characterized by peripheral pancytopenia despite normo- or hypercellular bone marrow. This is thought to be as a result of the apoptosis of haematopoietic bone marrow cells resulting in ineffective haematopoiesis. To clarify the relationship between prognosis and apoptosis and/or cell proliferation in the bone marrow, we studied 51 cases with MDS. Bone marrow biopsies were stained immunohistochemically for MIB-1 (marker for… CONTINUE READING


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