Evaluation of apoptosis and the glucocorticoid receptor in the cartilage growth plate and metaphyseal bone cells of rats after high-dose treatment with corticosterone.

@article{Silvestrini2000EvaluationOA,
  title={Evaluation of apoptosis and the glucocorticoid receptor in the cartilage growth plate and metaphyseal bone cells of rats after high-dose treatment with corticosterone.},
  author={Giuliana Silvestrini and Paola Ballanti and Francesca Romana Patacchioli and P. Mocetti and R di Grezia and Bianca Martin Wedard and Luciano Angelucci and Ermanno Bonucci},
  journal={Bone},
  year={2000},
  volume={26 1},
  pages={33-42}
}
A connection has been suggested between glucocorticoid-induced osteopenia and an increase in the apoptosis of bone cells, and between the dimerization of the glucocorticoid receptor (GR) and the development of apoptosis. On this basis, a study has been carried out on the relationships between the occurrence of apoptotic cells and their detectable GR content, and between apoptosis frequency and changes in histomorphometric variables, in the growth plate and secondary spongiosa of rat long bones… CONTINUE READING